PROBLEM TO BE SOLVED: To provide an evaluation method of stability for a preparation containing luliconazole and the preparation excellent in stability.SOLUTION: An evaluation method of stability for a preparation containing luliconazole measures a generation amount of the SE form of the luliconazole, a generation amount of the Z form of the luliconazole, and a generation amount of the amido form of the luliconazole represented by the following formula (1) when being stored under a severe condition or an acceleration condition. When the generation amount of the SE form, the generation amount of the Z form, and the generation amount of the amido form are respectively 5 mass% or less of the blending amount of the luliconazole, the preparation is determined to have the high stability. And a preparation conforming to the evaluation method is provided.COPYRIGHT: (C)2015,JPO&INPIT【課題】ルリコナゾールを含有する製剤の安定性の評価方法及び安定性の高い製剤の提供。【解決手段】ルリコナゾールを含有する製剤の安定性の評価方法であって、苛酷条件又は加速条件での保存による、ルリコナゾールのSE体の生成量、ルリコナゾールのZ体の生成量、及び下記式(1)に示されるルリコナゾールのアミド体の生成量を測定し、SE体の生成量、Z体の生成量、及びアミド体の生成量が、ルリコナゾールの配合量に対してそれぞれ5質量%以下であることを以て安定性の高い製剤であると判別する評価方法、並びに該評価方法に適合した製剤。【選択図】なし
