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PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN-ENCODING RNA
专利权人:
GLAXOSMITHKLINE BIOLOGICALS S.A.
发明人:
Andrew GEALL,Ayush VERMA
申请号:
US16714877
公开号:
US20200113830A1
申请日:
2019.12.16
申请国别(地区):
US
年份:
2020
代理人:
摘要:
Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass above 3 kDa but less than 11 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposome's exterior, wherein the average molecular mass of the polyethylene glycol is above 3 kDa but less than 11 kDa; and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases,
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