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PEGYLATED LIPOSOMES FOR DELIVERY OF IMMUNOGEN ENCODING RNA
专利权人:
Andrew Geall
发明人:
Andrew Geall,Ayush Verma
申请号:
US13819077
公开号:
US20130202684A1
申请日:
2011.08.31
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Nucleic acid immunisation is achieved by delivering RNA encapsulated within a PEGylated liposome. The RNA encodes an immunogen of interest. The PEG has an average molecular mass of between 1 kDa and 3 kDa. Thus the invention provides a liposome having a lipid bilayer encapsulating an aqueous core, wherein: (i) the lipid bilayer comprises at least one lipid which includes a polyethylene glycol moiety, such that polyethylene glycol is present on the liposomes exterior, wherein the average molecular mass of the polyethylene glycol is between 1 kDa and 3 kDa and (ii) the aqueous core includes a RNA which encodes an immunogen. These liposomes are suitable for in vivo delivery of the RNA to a vertebrate cell and so they are useful as components in pharmaceutical compositions for immunising subjects against various diseases.
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