Melissa A. Grunlan,Gerard L. Cote,Alexander A. Abraham,Ruochong Fei,Andrea K. Locke
申请号：
US15545811
公开号：
US20180021483A1
申请日:
2016.01.27
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane； wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area； wherein the membrane temperature is maintained at substantially the same temperature as the target area； wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.
