GRUNLAN, Melissa A.,COTE, Gerard L.,ABRAHAM, Alexander A.,FEI, Ruochong,LOCKE, Andrea K.
申请号：
EP16744019
公开号：
EP3250255A4
申请日:
2016.01.27
申请国别(地区):
EP
年份:
2018
代理人:
摘要：
The disclosure provides a method for cleaning an implanted medical device. In one embodiment, the method includes providing a medical device including a membrane； wherein the membrane comprises a thermoresponsive hydrogel including N-isopropylacrylamide (NIPAAm) or poly(N-isopropylacrylamide) (PNIPAAm), and a volume phase transition temperature (VPTT). The method also includes implanting the medical device into a target area； wherein the membrane temperature is maintained at substantially the same temperature as the target area； wherein temperature fluctuations within the target area that approach, meet and/or exceed the volume phase transition temperature induce deswelling or relative deswelling in the membrane and temperature fluctuations within the target area that are relatively lower and/or approach and/or fall below the volume phase transition temperature induce swelling or relative swelling in the membrane.
