The present invention refers to the use of the compounds E-6087 in a weekly dosage regime for the treatment of pain and inflammation associated to a degenerative joint disease such as osteoarthritis or a condition associated to any such disease such as lameness. The present invention is directed to the treatment of mammals, preferably of dogs.本發明係有關於以週劑量療程用於治療源自退化性關節疾病諸如骨關節炎的疼痛及發炎或源自於任何此種疾病的病況諸如跛行之化合物E-6087的用途。本發明係針對哺乳動物較佳為犬類之治療。