METHODS FOR TREATING HIV-ASSOCIATED NUEROLOGICAL DISEASE USING POLYAMINE ANALOGS

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专利权人:

PATHOLOGICA; LLC

发明人:

McGrath, Michael S.,Hadlock, Kenneth G.

申请号：

AU2013201090

公开号：

AU2013201090B2

申请日:

2013.02.26

申请国别(地区):

AU

年份:

2014

代理人:

摘要：

#$%^&*AU2013201090B220140206.pdf#####ABSTRACT The present application provides methods of treating HIV-associated neurological disease (HAND) comprising reducing proviral load of a subject with said disease by administering to the subject a therapeutically effective amount of a polyanine analog whereby reducing the proviral load in the subject, wherein the subject does not have AIDS-associated dementia or AIDS associated lymphoma. The polyamine analog may be mitoguazone (MGBG) or a salt thereof or N,N bis(3-ethylaminopropyl)-cis-but-2-ene-1,4-diamine tetrahydrochloride (CG47) or a salt thereof.

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