The present invention provides methods and compositions for facilitating weight loss in subjects who are undergoing a weight loss regimen by administration of thyroid hormones, for example, T2 alone, T2 in combination with T3, T2 in combination with T3 and T4, or T3 in combination with T4. In particular, subjects who have already experienced weight loss often are unable to continue to lose weight as the body experiences a famine response, i.e., hypothyroidism. By administration of the compositions of the present invention, for example, T2 alone, T2 in combination with T3, T2 in combination with T3 and T4, or T3 in combination with T4, subjects are able to return thyroid levels to normal and/or to reduce the levels of rT3 to normal, so as to allow the body to continue to lose weight.
