MEADOWS DAVID L.,KETELSON HOWARD ALLEN,DAVIS JAMES W.
申请号：
NZ60334511
公开号：
NZ603345A
申请日:
2011.05.04
申请国别(地区):
NZ
年份:
2014
代理人:
摘要：
Disclosed is a viscosity-stabilized ophthalmic formulation comprising a galactomannan, borate, and sorbitol wherein said galactomannan is guar or hydroxylpropyl guar wherein said galactomannan is present at a concentration of about 0.1 w/v% to about 2.0 w/v% and said borate is present at a concentration of about 0.2 w/v% to about 2.0 w/v% wherein sorbitol is present at a concentration of about 0.5 w/v% to about 5.0 w/v% and wherein the sorbitol stabilizes the viscosity of the formulation. Also disclosed is a method of stabilising an ophthalmic formulation with sorbitol and the use of an ophthalmic formulation as an eye lubricant or for administering pharmaceutical active agents to the eye.
