David BERK,Alexandre KAOUKHOV,Vilma SNIUKIENE,Carsten SCHMITZ
申请号：
US16632121
公开号：
US20200222432A1
申请日:
2018.07.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are methods of treating non-inflammatory lesions and symptoms thereof comprising administering to a subject in need thereof a therapeutically effective amount of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide or pharmaceutically acceptable salts thereof. In certain embodiments, a crystalline mono hydrochloride, mono mesylate, or mono sulfate salt of (4S,4aS,5aR,12aS)-4-(dimethylamino)-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is administered.
