Provided herein are methods of treating non-inflammatory lesions and symptoms thereof comprising administering to a subject in need thereof a therapeutically effective amount of (4S,4aS,5aR,12aS)-4-dimethylamino-3, 10, 12,12a- tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-l, 11-dioxo- 1,4,4a,5,5a,6,11, 12a-octahydro-naphthacene-2-carboxylic acid amide or pharmaceutically acceptable salts thereof. In certain embodiments, a crystalline mono hydrochloride, mono mesylate, or mono sulfate salt of (4S,4aS,5aR, 12aS)-4- (dimethylamino)-3, 10, 12, 12a-tetrahydroxy-7-[(methoxy(methyl)amino)methyl]- 1, 11-dioxo-1,4,4a,5,5a,6,11, 12a-octahydro- naphthacene-2-carboxylic acid amide is administered.
