A compound of Formula (Id) or a pharmaceutically acceptable salt thereof: ** Formula ** in which: Z2 is -N- or CR2 in which R2 is hydrogen or alkyl； ** Formula ** is a ring of formula ** Formula ** R6 and R7 are independently hydrogen, methyl, methoxy, fluorine, chlorine, trifluoromethyl, trifluoromethoxy, or cyano； -Z-EWG- is - (alkylene) -NR'CO-, - (alkylene) -NR'SO2-, ** Formula ** Each ring is optionally substituted with one or two substituents independently selected from alkyl, hydroxy, or halo and the carbonyl and sulfonyl groups in - (alkylene) -NR'CO-, - (alkylene) -NR'SO2-, ** Formula ** is bound to -C (CN)>； = CHRc； and each R 'is independently hydrogen or alkyl； and Rc is alkyl, haloalkoxy, substituted alkyl, cycloalkyl, cycloalkyleneNRdRe or cycloalkylene (alkylene) NRdRe (in which Rd and Re are independently hydrogen, alkyl, or cycloalkyl), or 3 to 6 membered saturated monocyclic heterocyclyl containing one or two heteroatoms selected from N, O, or S and optionally substituted with one or two substituents selected from hydroxy, alkyl or fluorine.Un compuesto de Fórmula (Id) o una sal farmacéuticamente aceptable del mismo: **Fórmula** en la que: Z2 es -N- o CR2 en el que R2 es hidrógeno o alquilo； **Fórmula** es un anillo de fórmula **Fórmula** R6 y R7 son independientemente hidrógeno, metilo, metoxi, flúor, cloro, trifluorometilo, trifluorometoxi, o ciano； -Z-EWG- es -(alquilen)-NR'CO-, -(alquilen)-NR'SO2-, **Fórmula** cada anillo está opcionalmente sustituido con uno o dos sustituyentes seleccionados independientemente entre alquilo, hidroxi, o halo y los grupos carbonilo y sulfonilo en -(alquilen)-NR'CO-, -(alquilen)-NR'SO2-, **Fórmula** está unido a -C(CN)>；=CHRc； y cada R' es independientemente hidrógeno o alquilo； y Rc es alquilo, haloalcoxi, alquilo sustituido, cicloalquilo, cicloalquilenNRdRe o cicloalquilen(alquileno)NRdRe (en los que Rd y Re son independientemente hidrógeno, alquilo, o cicloalquilo), o heterociclilo monocíclico saturado de
