ALKALOIDS AND THEIR PREPARATION AND APPLICATION AS ANTI-HSV-1 AGENTS

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专利权人:

发明人:

Changlun SHAO,Changyun WANG,Xiaofeng MU,Rufang XU

申请号：

US15722034

公开号：

US20180028523A1

申请日:

2017.10.02

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention provides alkaloids with formula I, II, III, IV, or V and their pharmaceutically acceptable salts, their preparation and their uses as antivirus drugs, for example, for treatment of HSV-1 infection. The alkaloids with formula I were isolated from the fermentation of marine fungus Scopulariopsis sp.(TA01-33) by means of column chromatography, such as positive phase silica gel column chromatography, etc. Alkaloids with formula II, III, IV and V were semisynthesized from compounds with formula I.

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