The present invention provides uses of a Cyperusrotundus extracts in the manufacture of composition for reducing the inflammation of epidermal keratinocytes induced by UV light, promoting the metabolism of epidermal keratinocytes and improving skin texture, skin pore size and reducing skin melanin content. The Cyperusrotundusextract is prepared by extractingCyperusrotundususing water, alcohols, or mixtures of water and alcohols as solvents.本發明提供一種水香稜萃取物用於降低皮膚角質細胞因照射紫外光導致皮膚發炎反應、促進皮膚角質代謝及改善皮膚紋理、毛孔大小與減少黑色素含量之醫藥組合物的用途,該水香稜萃取物係水香稜以水、醇、或醇水混合物之溶劑所萃取而得。