PURDUE RESEARCH FOUNDATION;ENDOCYTE; INC.;ENDOCYTE, INC.
发明人:
VLAHOV, IONTCHO R.,LEAMON, CHRISTOPHER P.,LOW, PHILIP S.,PARHAM, GARTH L.,CHEN, QINGSHOU
申请号：
CA2930581
公开号：
CA2930581A1
申请日:
2014.11.13
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Described herein are compounds, compositions, and methods for diagnosing and/or monitoring pathogenic disease using positron emission tomography. Also described are conjugates of the formula B-L-P, wherein B is a radical of a targeting agent selected from vitamin receptor binding ligands (such as folate), PSMA binding ligands, or PSMA inhibitors； L is a divalent linker comprising aspartic acid, lysine, or arginine, and P is a radical of an imaging agent or radiotherapy agent, such as a radionuclide or radionuclide containing group, or a radical of a compound capable of binding a radionuclide, such as a metal chelating group.
