Barbara Slusher,Michael Nedelcovych,Rana Rais,Clemens Kratochwil
申请号：
US16604663
公开号：
US20200069706A1
申请日:
2018.04.11
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The use of a class of prodrugs of 2-PMPA that alter tissue distribution of 2-PMPA to non-prostate tissues is disclosed. The presently disclosed prodrugs preferentially distribute to healthy tissues including the kidney, lacrimal glands, and salivary glands, which represent sites of off-target binding and toxicity for PSMA-targeted prostate cancer imaging agents and therapies. Accordingly, the 2-PMPA prodrugs can be used to pretreat, bind to, and shield the kidney and salivary glands from PSMA-targeted cytotoxic or radiotherapy.
