Caninised and chimeric antibodies and antigen binding fragments thereof which bind specifically to canine tumour necrosis factor and inhibit the ability of canine TNF to bind to the TNFR1 receptor are provided. The invention further extends to nucleic acids encoding same and to methods of treating chronic inflammatory disease such as arthritis in a canine using said antibodies and/or nucleic acids.提供犬化抗體及嵌合抗體及其抗原結合片段,其特異性結合至犬腫瘤壞死因子且抑制犬TNF結合至TNFR1受體之能力。本發明進一步擴展至編碼其之核酸及使用該等抗體及/或核酸治療犬之慢性發炎性疾病(諸如關節炎)之方法。
