This invention relates to binding molecules that bind specifically to TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) and cadherin-17 (CDH17) and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.本發明係關於特異性結合至TNF相關細胞凋亡誘導配體受體2 (TNF-related apoptosis-inducing ligand receptor 2;TRAILR2)及鈣黏蛋白-17 (cadherin-17;CDH17)之結合分子及其於藥劑中之用途、包含該等結合分子之醫藥組合物及使用該等結合分子作為藥劑來治療及/或預防癌症之方法。