Manel Maria Cascallo Piqueras,Alena Gros,Ramon Alemany Bonastre
申请号：
US12557031
公开号：
US08974777B2
申请日:
2009.09.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant in treating cancer. Said mutant virus may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.
