CASCALLO PIQUERAS, MANEL MARIA,GROS, ALENA,ALEMANY BONASTRE, RAMON
申请号：
CA2680659
公开号：
CA2680659C
申请日:
2008.03.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present invention relates to an adenovirus wherein said adenovirus replicates and it contains a mutation in the endoplasmic reticulum retention domain of E3-19K, and to the use of said mutant in treating cancer. Said mutant virus may also contain other mutations and insertions of DNA sequences used to confer selectivity and antitumor potency. The invention has application in the field of cancer therapy.
