METHODS FOR INCREASING THE STABILIZATION OF HYPOXIA INDUCIBLE FACTOR-1 ALPHA

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专利权人:

AERPIO THERAPEUTICS INC.

发明人:

SHALWITZ, ROBERT,GARDNER, JOSEPH, H.

申请号：

IN4949DEN2012

公开号：

IN4949DEN2012A

申请日:

2012.06.05

申请国别(地区):

IN

年份:

2015

代理人:

摘要：

Disclosed herein are methods for controlling the activity of hypoxia- inducible transcription factor 1 -alpha (HIF- lα) and diseases, conditions, or syndromes related thereto, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia. Further disclosed are pharmaceutical compositions comprising HIF- lα prolyl hydroxylase inhibitors useful in treating diseases, conditions, and/or syndromes related thereto the activity of HIF-I α.

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