CHUA, PETER C.,PIERRE, FABRICE,WHITTEN, JEFFREY P.
申请号：
ES07841767
公开号：
ES2528316T3
申请日:
2007.08.31
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound with a structure of formula XIII, XIV, XV or XVI: ** Formula ** or a pharmaceutically acceptable salt thereof, where: Z5 is N or CR6A； each R6A, R6B, R6D and R8 independently is H or a C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 heteroalkyl, C3-C8 heterocycloalkyl, C2-C8 alkenin, C3-C8 alkylaryl, C2-C8 heteroalkenyl, heterocycloalkenyl C3-C8, C2-C8 alkynyl, C2-C8 heteroalkynyl, C1-C8 acyl, C6-C10 aryl, C5-C12 heteroaryl, C7-C12 arylalkyl or optionally substituted C6-C12 heteroarylalkyl. or each R6A, R6B, R6D and R8 independently is halo, CF3, OR, NR2, NROR, NRNR2, SR, SOR, SO2R, SO2NR2, NRSO2R, NRCONR2, NRCOOR, NRCOR, CN, COOR, bioisposter carboxy, CONR2, OOCR, COR or NO2, R9 is independently a C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 heteroalkyl, C3-C8 heterocycloalkyl, C2-C8 alkenyl, C3-C8 cycloalkenyl, C2-C8 heteroalkenyl, C3-C8 heterocycloalkenyl, alkynyl group C2-C8, C2-C8 heteroalkynyl, C1-C8 acyl, C6-C10 aryl, C5-C12 heteroaryl, C7-C12 arylalkyl or optionally substituted C6-C12 heteroarylalkyl or R9 is independently halo, OR, NR2, NROR, NRNR2, SR , SOR, SO2R, SO2NR2, NRSO2R, NRCONR2, NRCOOR, NRCOR, CN, COOR, CONR2, OOCR, COR or NO2, where each R is independently H or a C1-C8 alkyl group, C3-C8 cycloalkyl, C2-C8 heteroalkyl , C3-C8 heterocycloalkyl, C2-C8 alkenin, C3-C8 cycloalkenyl, C2-C8 heteroalkenyl, C3-C8 heterocycloalkenyl, C2-C8 alkynyl, C2-C8 heteroalkynyl, C1-C8 acyl, C6-C10 aryl, C-heteroaryl 5-C10, C7-C12 arylalkyl or C6-C12 heteroarylalkyl, and where two Rs in the same or adjacent atoms can be joined to form a 3-8 atom ring, which optionally contains one or more N, O or S ； and each R group and each ring formed by the union of two R groups together, is optionally substituted with one or more substituents selected from halo,>； = O,>； = N-CN, N-OR ',>； = NR' , OR ',>； = NR'2, SR', SO2R ', SO2NR'2, NR'SO2R', NR'CONR'2, NR'COOR ', NR'COR', CN, COOR ', CONR'2, OOCR ', COR' and NO2.Un compuesto con una estructura de fórmula XIII, XIV, XV o XVI:**
