ALAGARSAMY, SUDARKODI,JIANG, GUANGCHENG,RIVIERE, PIERRE,SCHTEINGART, CLAUDIO,SUEIRAS-DIAZ, JAVIER,WISNIEWSKI, KAZIMIERZ
申请号：
ES10825678
公开号：
ES2530615T3
申请日:
2010.10.21
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
Compound of formula I: ** formula ** in which: R1 is selected from the group consisting of H, alkyl, aralkyl and aryl； a is chosen from the group consisting of 0, 1, 2, 3, 4, 5, 6 and 7； R2 is a heteroaryl； b is 1 or 2； R3 and R4 are each independently selected from the group consisting of H and alkyl； c and d are each chosen independently of the group consisting of 0 and 1； R5 is methyl； e is 3； R6 is selected from the group consisting of H, alkyl, cycloalkyl, aryl, biaryl, heteroaryl and -C (O) -NH2, in which the amino acid formed with the side chain in R6 is in the D configuration； f is chosen from the group consisting of 0, 1, 2 and 3, with the proviso that if R6 is different from H, f is not 0； R7 is selected from the group consisting of alkyl, cycloalkyl, aryl, biaryl, diaryl, heteroaryl and -C (O) -NH2； g is chosen from the group consisting of 1, 2 and 3； R8 is selected from the group consisting of H, alkyl, -CH (OH) -CH3； h is chosen from the group consisting of 0, 1, 2 and 3； X1 is Gln or Arg； X2, X3 and X4 are each independently present or absent and, if present, are independently selected from the group consisting of Val, Leu, Ile, Ser, Thr, Asp and Glu； Z is NR9R10 or OH, wherein: R9 and R10 are each independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, heteroaralkyl, aralkyl and (CH2) x - [(CH2) 2- O] and- (CH2) x- [NH-C (O) -CH2-O-CH2] zC (O) -NHR11, in which: R11 is H or - [(CH2) 2-O] and- ( CH2) xC (O) -NH2 each x is independently selected from the group consisting of 0, 1, 2 and 3, each and is independently selected from the group consisting of 3, 4, 5 and 6, z is 0 or 1, and R9 and R10 are optionally linked to form a 4- to 7-membered ring that may be a heterocycle or a heteroaryl； and pharmaceutically acceptable salts thereof.Compuesto de fórmula I:**fórmula** en la que: R1 se elige del grupo que consiste en H, alquilo, aralquilo y arilo； a se elige del grupo que consiste en 0, 1, 2, 3, 4, 5
