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Method for aligning cells and applying homogenous strain throughout deformable engineered tissue constructs
专利权人:
Matthew Thomas Harris
发明人:
Matthew Thomas Harris
申请号:
US13568057
公开号:
US08691262B2
申请日:
2012.08.06
申请国别(地区):
US
年份:
2014
代理人:
摘要:
A process creates a homogenous sheet of engineered tissue comprised of encapsulated cells and a deformable engineered tissue construct. In the embodiment consisting of a collagen construct with encapsulated cells capable of contracting the matrix, the collagen fibers and encapsulated cells are aligned during the process. An apparatus can deliver controlled homogenous strain and stress to a thin sheet of engineered tissue. This process allows application of dynamic, uniform tensile loading to deformable engineered tissue constructs and creation of an engineered cell-delivery construct with alignment of both fibers and encapsulated cells.
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