Quinazoline derivant and preparation method thereof农业专利-农业学术服务平台

专利权人:: LTD.;北京賽林泰醫藥技術有限公司;正大天晴药业集团股份有限公司;北京赛林泰医药技术有限公司;連雲港潤眾;CHIA TAI TIANQING PHARMACEUTICAL GROUP CO.;CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.;Lianyungang Runzhong Pharmaceutical Co., Ltd.;CENTAURUS BIOPHARMA CO., LTD.;正大天晴藥業集團股份有限公司;连云港润众制药有限公司

发明人:: XIAO, Dengming,校登明,ZHU, Yan,朱岩,HU, Yuandong,胡远东,胡遠東,WANG, Huting,王虎庭,LI, Jijun,李继军,李繼軍,PENG, Yong,彭勇,ZHANG, Hui,张慧,張慧,LUO, Hong,罗鸿,羅鴻,KONG, Fansheng,孔凡胜,孔凡勝,HAN, Yongxin,韩永信,韓永信

摘要：: The purposes in the drug for treating and preventing tumour is prepared the present invention relates to quinazoline derivant of formula (I) and preparation method thereof, the pharmaceutical composition comprising formula (I) compound and its with what. The compounds of this invention can irreversibly prevent the autophosphorylation of EGFR, and effectively inhibit the signal transduction of cancer cell, show higher in vitro and in vivo anti-tumor activity.本發明涉及式（I）的喹唑啉衍生物及其製備方法、包含式（I）化合物的藥物組合物及其用於製備治療和預防腫瘤的藥物中的用途。本發明化合物可以不可逆地阻止EGFR的自身磷酸化，並且有效的抑制癌細胞的信號傳導，顯示出更高的體外和體內抗腫瘤活性。