Methods for reversing the effects of tumor microenvironment using chimeric cytokine receptors

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专利权人:

ベイラー カレッジ オブ メディスン

发明人:

リーン、アン、マリー,ヴェラ、ジュアン、エフ．,ヴェラ、ジュアン、エフ.

申请号：

JP2014503979

公开号：

JP6066991B2

申请日:

2012.04.05

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

Disclosed are compositions and methods related to rendering ineffective Thl T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Thl immunostimulatory/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IE 10, IE 13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/