INVERSION DES EFFETS DU MICROENVIRONNEMENT TUMORAL A L'AIDE DE RECEPTEURS DE CYTOKINE CHIMERES

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专利权人:

BAYLOR COLLEGE OF MEDICINE

发明人:

LEEN, ANN MARIE,VERA, JUAN F.

申请号：

CA2832569

公开号：

CA2832569A1

申请日:

2012.04.05

申请国别(地区):

CA

年份:

2012

代理人:

摘要：

Disclosed are compositions and methods related to rendering ineffective Th1 T cells resistant to the inhibitory cytokine milieu present in a cancer microenvironment. Tumor-specific T cells are modified to employ a chimeric receptor that binds inhibitory/suppressive cytokines and converts their intracellular consequences to a Th1 immunostimulaotyr/activating signal. The T cells employ a chimeric antigen receptor having exodomains for IL10, IL13 and/or IL4 fused with the signal transducing endodomains for IL2 and/or IL7.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/