MASSACHUSETTS INSTITUTE OF TECHNOLOGY;WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
发明人:
LINQUIST, SUSAN L.,BUCHWALD, STEPHEN L.,TARDIFF, DANIEL,JUI, NATHAN
申请号：
CA2906194
公开号：
CA2906194A1
申请日:
2014.03.17
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof.
