Whitehead Institute for Biomedical Research;Massachusetts Institute of Technology
发明人:
Susan L. Lindquist,Stephen L. Buchwald,Daniel Tardiff,Nathan Jui
申请号：
US14776184
公开号：
US09790188B2
申请日:
2014.03.17
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and pharmaceutical compositions thereof. The present invention also provides methods and kits using the inventive compounds and pharmaceutical compositions for treating and/or preventing diseases associated with protein aggregation, such as amyloidoses (e.g., Parkinson's disease and Alzheimer's disease), treating and/or preventing neurodegenerative diseases, treating and/or preventing diseases associated with Tar DNA binding protein 43 kDa, reducing or preventing protein aggregation, and/or modulating E3 ubiquitin ligase in a subject in need thereof.
