Hansen, Genevieve,Garland, William A.,Sabbadini, Roger A.
申请号：
AU2012202713
公开号：
AU2012202713A1
申请日:
2012.05.04
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012202713A120120531.pdf#####IMMUNE-DERIVED MOIETIES REACTIVE AGAINST LYSOPHOSPHATIDIC ACID 5 ABSTRACT Compositions and methods for producing monoclonal antibodies and their derivatives reactive against bioactive lipid targets are described. These compositions include derivatized lipids, each of which comprises a bioactive lipid that having a polar head group and at least one hydrocarbon chain (e.g., a lysolipid such as lysophosphatidic 10 acid or sphingosine- 1-phosphate) in which a carbon atom has been derivatized with a pendant reactive group immunogens made by linking a derivatized lipid to a carrier moiety (e.g., a carrier protein, polyethylene glycol, colloidal gold, alginate, or a silicone bead) monoclonal antibodies and derivatives produced by immunizing an animal with such an immunogen and therapeutic and diagnostic compositions containing such 15 antibodies and antibody derivatives. Methods for making such derivatized lipids, immunogens, and monoclonal antibodies and derivatives, methods for detecting such antibodies once generated, and therapeutic and diagnostic methods for using such antibodies and derivatives, are also described. 20
