ANTI-A GLOBULOMER ANTIBODIES, ANTIGEN-BINDING MOIETIES THEREOF, CORRESPONDING HYBRIDOMAS, NUCLEIC ACIDS, VECTORS, HOST CELLS, METHODS OF PRODUCING SAID ANTIBODIES, COMPOSITIONS COMPRISING SAID ANTIBODIES, USES OF SAID ANTIBODIES AND METHODS OF USING SAID ANTIBODIES
BORIS LABKOVSKY,STEFAN BARGHORN,HEINZ HILLEN,ULRICH EBERT,PATRICK KELLER,ANDREAS STRIEBINGER
申请号：
PT06818937
公开号：
PT1954718E
申请日:
2006.11.30
申请国别(地区):
PT
年份:
2014
代理人:
摘要：
Anti-A² globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-A² globulomer antibodies having a binding affinity to A²(20-42) globulomer that is greater than the binding affinity of the antibody to A²(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimers disease and other amyloidoses.
