Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał
BARGHORN, STEFAN,EBERT, ULRICH,HILLEN, HEINZ,KELLER, PATRICK,STRIEBINGER, ANDREAS,LABKOVSKY, BORIS
申请号：
PL10178394
公开号：
PL2289909T3
申请日:
2006.11.30
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
Anti-A² globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies. The present invention relates to anti-A² globulomer antibodies having a binding affinity to A²(20-42) globulomer that is greater than the binding affinity of the antibody to A²(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimer's disease and other amyloidoses.
