Jayne CHIN,Robert Alan Goodnow, JR.,Matthew Michael Hamilton,Achyutharao Sidduri
申请号：
US14373669
公开号：
US20150306130A1
申请日:
2013.01.24
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (α4β1) and alpha-V-beta-3 (αVβ3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.
