CHIN, JAYNE,GOODNOW, ROBERT ALAN, JR.,HAMILTON, MATTHEW MICHAEL,SIDDURI, ACHYUTHARAO
申请号：
CA2854251
公开号：
CA2854251A1
申请日:
2013.01.24
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention relates to the chitosan polymer derivatives of formula I: and pharmaceutically acceptable salts and esters thereof, wherein Y, X1, X4, R1, R2, and n are defined in the detailed description and claims. The chitosan polymer derivatives of formula I bind to or associate with alpha-4-beta-1 (a4ß1) and alpha-V-beta-3 (a Vß3) integrin dimers and can be used in delivery formulations to deliver drugs, nucleic acids, or other therapeutic compounds to tissues or cells expressing such integrins.
