A compound represented by the general formula (I): ** Formula * + in which R1 represents (1) COOH, (2) COOR2, (3) CH2OH or (4) CONR3R4, R2 represents a C1-C6 alkyl group optionally substituted with a hydroxy group, ONO2 or a C1-4 alkoxy group, R3 and R4 each independently represent a hydrogen atom, or a C1-C4 alkyl group optionally substituted with ONO2, R5 represents a halogen atom, a hydroxy group or a C1-4 alkoxy group, Z represents (1) - (CH2) m-, (2) - (CH2) n- CH>； = CH-, (3) - (CH2) pA-CH2- or (4) ring 1, A represents an oxygen atom, or a sulfur atom, W represents a C1-6 alkyl group optionally substituted with 1 to 5 substituents selected from the group consisting of (1) a hydroxy group, (2) an oxo group , (3) a halogen atom, (4) a C1-4 alkyl group, (5) a C1-4 alkoxy group, (6) ring 2, (7) -O-ring 2 and (8) -S- ring 2, ring 1 and ring 2 each independently represent a C3-10 carbocycle or a heterocycle of 3 to 10 members, optionally substituted with 1 to 5 substituents selected from the group consisting of (1) a halogen atom, (2) CF3, (3) OCF3, (4) a C1-4 alkoxy group, (5) a C1-4 alkyl group, (6) a hydroxy group and (7) a nitrile group, m represents an integer from 1 to 6, n represents an integer from 1 to 4, p represents an integer from 1 to 4 , ** Formula ** represents a single link or a double link, ** Formula ** represents the α configuration, ** Formula ** represents the ß configuration, and ** Formula ** represents the α configuration, the ß configuration or an arbitrary mixture thereof, or a salt thereof or a solvate thereof.Un compuesto representado por la formula general (I):**Fórmula*+ en la que R1 representa (1) COOH, (2) COOR2, (3) CH2OH o (4) CONR3R4, R2 representa un grupo alquilo C1-C6 opcionalmente sustituido con un grupo hidroxi, ONO2 o un grupo alcoxi C1-4, R3 y R4 representan cada uno independientemente un atomo de hidrogeno, o un grupo alquilo C1-C4 opcionalmente sustituido con ONO2, R5 representa un atomo de halogeno, un grupo hidroxi o u
