PARK, SEUNG CHUN,박승춘,CHOI, MYUNG JIN,최명진,HWANG, MIN HEE,황민희,LEE, SEUNG JIN,이승진
申请号：
KR1020110036087
公开号：
KR1020120118612A
申请日:
2011.04.19
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: A complex antibiotic composition for animals including enrofloxacin and trimethoprim and a treating and preventing method for bacterial infection of animals using the same are provided to maintain excellent effects and to reduce the content of relatively expensive enrofloxacin.CONSTITUTION: A complex antibiotic composition for animals includes enrofloxacin and trimethoprim. The mixing ratio of the trimethoprim to enrofloxacin is 3:7-7:3. The complex antibiotic composition is used as a feed admixture, an oral preparation or an injection. The bacterial infection is prevented and treated by using complex antibiotic composition for animals. The animals are domestic animals composed of hen, pig, cattle, horse, dog, duck, goat and sheep, the fresh water fishes consisting of trout, and carp and eel, and sea water fishes consisting of flatfish, sebastes schelegeli, sea bream and lobster.COPYRIGHT KIPO 2013[Reference numerals] (AA) Abdominal administrating ENR(9 mg/kg), TMP(21 mg/kg) and ET37 into a rat(30 mg/kg) (BB) Collecting blood from fine vein of the rat (CC) Centrifugation at 5000 rpm for 10 minutes (DD) Obtaining plasma and storing at -70 deg. Celsius (EE) Adding 5 micro grams of 20% triethylamine to 50 micro liters of plasma (FF) Voltexing for 1 minute (GG) Obtaining and filtering 30 micro liters of the upper layer solution(0.45 &mum) (HH) Injecting in to HPLC system (I1) Mobile phase: 0.5% trithethylamin which contains 1% acetic acid=11.89 (I2) Flow rate:1.6ml/minute (I3) Detection wave: 280 nm (J1) Mobile phase: 0.5% trithethylamin which contains 1% acetic acid=9.91 (J2) Flow rate:1.5 ml/minute (J3) Detection wave:270nm (KK) Voltexing for 1 minute본 발명은 신규 동물용 복합항생제 조성물에 관한 것으로서, 더욱 상세하게는 최적 혼합비로 구성된 엔로프록사신과 트리메토프림의 약제학적 유효량을 포함하는 동물용 복합항생제 조성물에 관한 것이다.본 복합항생제 조성물은 가축 및 어류에서 발생하는 넓은 범위의 세균성 질병에 대한 치료와 예방에 유용하며, 그 적절한 혼합으로 우수한 효과를 유지하면서도 상대적으로 값비싼 엔로프록사신의 함량을 감소시킴으로써 축산농가의 생산원가를 절감하고 약품의 축체 내 잔류도 효율적으로 최소화할 수 있다.
