Bo ÖBERG,Anders BROBERG,Bengt GUSS,Jolanta LEVENFORS,Joakim BJERKETORP,Christina NORD
申请号：
US15988414
公开号：
US20180280417A1
申请日:
2018.05.24
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a composition comprising a first compound which is a nucleoside analogue capable of inhibiting a bacterial colonisation or infection of a subject； a second compound which is capable of decreasing mitochondrial toxicity of said nucleoside analogue and surprisingly enhance the antibacterial effect of the combination； and a third compound capable of decreasing the concentration in bacteria of nucleosides and/or nucleotides known to compete with nucleoside analogues. The first compound may be AZT, FdUrd, 5-fluorouracil, BrdUrd, IdUrd, didanosine or gemcitabine； the second compound may be uridine or a uridine-comprising compound； and the third compound may be iclaprim； trimethoprim； or a compound comprising trimethoprim, such as trimethoprim-sulfa.
