OBERG, BO,BROBERG, ANDERS,GUSS, BENGT,LEVENFORS, JOLANTA,BJERKETORP, JOAKIM,NORD, CHRISTINA
申请号：
CA3007831
公开号：
CA3007831A1
申请日:
2017.01.27
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention relates to a composition comprising a first compound which is a nucleoside analogue capable of inhibiting a bacterial colonisation or infection of a subject； a second compound which is capable of decreasing mitochondrial toxicity of said nucleoside analogue and surprisingly enhance the antibacterial effect of the combination； and a third compound capable of decreasing the concentration in bacteria of nucleosides and/or nucleotides known to compete with nucleoside analogues. The first compound may be AZT, FdUrd, 5-fluorouracil, BrdUrd, IdUrd, didanosine or gemcitabine； the second compound may be uridine or a uridine-comprising compound； and the third compound may be trimethoprim or a compound comprising trimethoprim, such as trimethoprim-sulfa.
