HEAT SHOCK PROTEIN DEFICIENCIES AS MODEL SYSTEMS FOR BRAIN PATHOLOGY AND CANCER

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专利权人:

MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC.;MIVECHI, NAHID, F.;EROGLU, BINNUR;MOSKOFIDIS, DIMITRIOS

发明人:

MIVECHI, NAHID, F.,EROGLU, BINNUR,MOSKOFIDIS, DIMITRIOS

申请号：

WO2010US20446

公开号：

WO2010080962(A3)

申请日:

2010.01.08

申请国别(地区):

世界知识产权组织国际局

年份:

2011

代理人:

摘要：

The invention provides non-human transgenic animals as models of neurodegenerative brain pathology, including, but not limited to, Alzheimer's disease (AD), and cancer. The non-human transgenic animals of the present invention include an exogenous DNA that reduces or eliminates the expression and/or function of a molecular chaperone, including, but not limited to heat shock protein 110 (Hspl 10) or heat shock protein 70 (Hsp70). These non-human transgenic animals may be used in methods of screening and identifying compounds useful for the prevention and/or treatment of neurodegenerative brain pathology and/or cancer.

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中国工程科技知识中心

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http://www.ckcest.cn/home/