A process and related system and computer program product for constructing a personalized contacting interface for a facial mask, comprising the steps of: providing a three-dimensional (3D) reference model representative of a human face; identifying in the reference model a desired contact area circumscribing one or more facial regions; generating a digital design model of a contacting interface, the digital design model having a perimeter configured to provide a continuous air seal along the desired contact area of the reference model; receiving a 3D facial target model corresponding to the face of a subject; performing an elastic transformation of the reference model to conform the reference model to the target model; modifying said perimeter of said digital design model based on the deformed reference model; and using said modified digital design model to generate a set of manufacturing instructions for a contacting interface personalized for said subject.