Compounds derived from 5.7 - imidazo [1,2-c] pyrimidine substituted inhibitors of jak Kinases； Preparation Process； Pharmaceutical Composition and Method for the treatment of inflammatory and autoimmune diseases, organ transplant rejection and Neoplasms.
MUNSON MARK C,KRASER CHRISTOPHER F,LAIRD ELLEN,ROBINSON JOHN E,BOYS, MARK LAURENCE,BURGES, LAURENCE E.,EARY, C. TODD,GRONEBERG, ROBERT,HACHE, BRUNO P.,HICKEN ERIK JAMES,MORENO DAVID A,REN LI,SCHLACHTE
申请号：
CL2014000931
公开号：
CL2014000931A1
申请日:
2014.04.11
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R1, R2, R3, R4, R5, R6, X1 and X2 have the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.COMPUESTOS DERIVADOS DE 5,7-IMIDAZO[1,2-C]PIRIMIDINAS SUSTITUIDAS, INHIBIDORES DE CINASAS JAK； PROCEDIMIENTO DE PREPARACION DE LOS COMPUESTOS； COMPOSICIONES FARMACOLOGICAS； UTILES PARA EL TRATAMIENTO DE UNA ENFERMEDAD INMUNITARIA,TAL COMO RECHAZO DE TRANSPLANTE DE ORGANOS O NEOPLASIA.
