- pirrolidinil derived compounds of N, n '- pirazolil - urea, thiourea, guanidine and SACCHARIN as inhibidpres TrkA kinase； Preparation Process； Pharmaceutical Composition and Use thereof for treating a disease or Disorder selected from pain, cancer, inflammation, among others.
KERCHER TIMOTHY,ALLEN SHELLEY,BRANDHUBER BARBARA J.,KOLAKOWSKI GABRIELLE R.,WINSKI, SHANNON, L.
申请号：
CL2015001261
公开号：
CL2015001261A1
申请日:
2015.05.11
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, or solvates or prodrugs thereof, where R 1 , R 2 , R a , R b , R c , R d , X, Ring B, and Ring C are as defined herein, and wherein Ring B and the NH-C(=X)-NH moiety are in the trans configuration, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis or pelvic pain syndrome.COMPUESTOS DERIVADOS DE DE N-PIRROLIDINIL, N'-PIRAZOLIL-UREA, TIOUREA, GUANIDINA Y CIANOGUANIDINA COMO INHIBIDPRES DE TRKA CINASA； PROCESO DE PREPARACION； COMPOSICIÓN FARMACEUTICA； Y SU USO PARA TRATAR UNA ENFERMEDAD O TRASTORNO SELECCIONADO DE DOLOR, CANCER, INFLAMACION, ENTRE OTROS.
