A therapeutic treatmentdevice, system and method for improvingadministration of a temperature sensitivedrug into a tissue on the body of apatient at a drug injection site are disclosed.The device includes a treatmentelement with a controllable heating elementin temperature communicativecontact with the tissue adjacent to thedrug injection site. The controllableheating element is configured to heatthe tissue adjacent to the drug injectionsite to a controllable temperature butdoes not heat the injected drug above apredetermined limiting temperature,above which degradation of the injecteddrug may occur.