Compositions and methods for determining post-transfusion survival or toxicity of red blood cells (RBC) and the suitability of RBCs for transfusion by measuring the levels of one or more markers in a red blood cell sample are provided. The method comprising the steps of: a) measuring the levels of one or more markers in a RBC sample selected from the group consisting of Cytidine, 5-Methylcytidine, N4-Actelcytidine, 9-HODE, 13-HODE, Prostaglandin E2, 5-HETE, 12-HETE, 15-HETE, arachdonic acid, 1- palmitoylglycerophosphoinositol, 1-stearoylglycerophosphoinositol, 13, 14-dihydro-15-ketoprostaglandin E2, and the reticulocyte count of a blood donor at the time of donation； b) comparing the level of the one or more markers in the RBC sample with the level of the one or more markers present in a control sample, wherein a higher or lower level of the one or more markers in the RBC sample is indicative of a lower RBC storage quality.L'invention concerne des compositions et des procédés pour déterminer la survie post-transfusion ou la toxicité d'érythrocytes et l'aptitude d'unités d'érythrocytes pour la transfusion par mesure des niveaux d'un ou de plusieurs marqueurs dans un échantillon d'érythrocytes.
