METHODES DE PREVENTION DE L'ALLO-IMMUNISATION DE PLAQUETTES ET DE LA PERIODE REFRACTAIRE DE PLAQUETTES ALLO-IMMUNES ET INDUCTION DE LA TOLERANCE DANS DES RECEVEURS TRANSFUSES
Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. Methods are provided to modify donor whole blood or platelets prior to transfusion by leukoreduction filtration and other forms of pathogen reduction. The provided methods are directed to prevent or reduce alloimmune platelet refractoriness in transfusion recipients.