The present invention relates to a medicament delivery device (10) comprising a housing (12, 14)； a medicament container holder (90), arranged movable in relation to said housing (12, 14) and capable of accommodating a medicament container (92)； an biased activator (160) comprising a plunger rod (164), which plunger rod (164) is arranged to act on the medicament container (92) for delivering a dose of medicament through a medicament delivery member (102 when said biased activator (160) is operated； a manually operable dose setting member (72) operably connected to both said housing and said medicament container holder such that manual operation of said dose setting member (72) will cause the medicament container holder (90) with the medicament container (92) to move towards said plunger rod (164) for setting a dose of medicament to be delivered； a dose drum (56) releasably connected to the dose setting member (72) through a releasable connection mechanism (68, 84I) such that when the dose setting member is operated, said dose drum (56) is displaced from an initial position to a set dose position； a release mechanism (116) operably connected to said biased activator (160), wherein, when said plunger rod (164) is moved to an end position of the dose delivery operation, said release mechanism (116) is arranged to act on said connection mechanism (68, 84I) for releasing said dose drum (56) from said dose setting member (72). The invention is characterised in that said release mechanism is arranged with a locking mechanism (130, 84II) arranged to lock said dose setting member (72) from displacement as the connection mechanism (68, 84I) is operated for releasing said dose drum (56) from said dose setting member (72).本發明有關藥物輸送裝置(10)，包含外殼(12、14)；藥物容器夾具(90)，被配置成可關於該外殼(12、14)運動及能夠容納藥物容器(92)；經偏向之啟動器(160)，包含柱塞桿(164)，該柱塞桿(164)被配置來作用在該藥物容器(92)上，用於當該經偏向的啟動器(160)被操作時將一劑量藥物輸送經過藥物輸送構件(102)；可手動操作之劑量設定構件(72)，其可操作地連接至該外殼及該藥物容器夾具兩者，使得該劑量設定構件(72)的手動操作將造成具有該藥物容器(92)之藥物容器夾具(90)運動朝該柱塞桿(164)，
