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Novel KCNQ potassium channel agonist, and preparation method therefor and use thereof
专利权人:
Chinese Academy of Sciences;Shanghai Institute of Materia Medica
发明人:
Nan, Fajun,Li, Min,Gao, Zhaobing,Zhang, Yangming,Hu, Haining,Xu, Haiyan,Liu, Huanan,Pi, Xiaoping
申请号:
AU2015252640
公开号:
AU2015252640A1
申请日:
2015.04.22
申请国别(地区):
AU
年份:
2016
代理人:
摘要:
The present invention provides a compound with a structure represented by general formula I or a pharmaceutically acceptable salt thereof, a preparation method for the compound or the salt, and a use of the compound or the pharmaceutically acceptable salt thereof in the preparation of medicaments for treating nervous system diseases, such as epilepsy, convulsion, neuropathic pain, acute ischemic stroke or neurodegenerative diseases. Compared with Retigabine, the compound of the present invention has better brain tissue absorption. Moreover, the compound provided by the present invention not only has greatly improved efficacy, but also has far fewer neurological side effects than Retigabine, and therefore has a wider safe window.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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