This invention relates to a compound compositions for improving neurodegenerative diseases, especially a compound compositions consists of Longan (Dimorcarpus longan Lour.) flower extracts, green propolis, and Taiwan unique orchid polyphenol for improving neurodegenerative diseases. The compound composition is capable of increasing the concentration of n-3 unsaturated fatty acids in the brain, lowering the concentration of n-6 polyunsaturated fatty acids in the brain, and increasing the concentration of the brain derived neurotrophic factor, lowering the activity of monoamine oxidase in cells and increasing the concentration of the brain derived neurotrophic factor in cells, so as to postponing the aging of nerve cells for achieving the efficacy of improving neurodegenerative diseases.本發明係有關一種用以改善神經退化性疾病之複方組成物,特別係為一種由龍眼花萃取物、綠蜂膠及國蘭多酚所組成之複方組成物,作為改善神經退化性疾病之用途。該複方組成物可提昇腦中n-3不飽和脂肪酸濃度、降低腦中n-6不飽和脂肪酸濃度、提昇腦中腦源性神經滋養因子濃度、降低細胞中單胺氧化酶活性、提昇細胞中腦源性神經滋養因子濃度等功效,藉以延緩神經細胞老化現象,進而達到改善神經退化性疾病的功效。