CHOSUN UNIVERSITY;조선대학교산학협력단;INDUSTRY-ACADEMIC COOPERATION FOUNDATION;INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY
发明人:
CHOI, HOO KYUN,최후균,CHUN, MYUNG KWAN,전명관,PARK, JUN HYUNG,박준형
申请号：
KR1020110074618
公开号：
KR1020130013157A
申请日:
2011.07.27
申请国别(地区):
KR
年份:
2013
代理人:
摘要：
PURPOSE: A solid dispersion of cilostazol and polymethacrylate copolymers, and a pharmaceutical composition containing the same are provided to quickly release cilostazol and to reduce the dosage. CONSTITUTION: A solid dispersion with polymethacylate copolymers contains cilostazol. The copolymer is a copolymer of methacrylic acid and methyl methacrylate, a copolymer of methacrylic acid and ethyl acrylate, an ammonio methacrylate, or a copolymer of butyl methacrylate, (2-dimethyl aminoethyl)methacrylate, and methyl methacrylate. The solid dispersion additionally contains one or more polymers selected from a group consisting of hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, crospovidone, or a copolymer of vinylpyrrolidone and vinyl acetate. An oral pharmaceutical composition contains the solid dispersion and a pharmaceutically acceptable additive. [Reference numerals] (AA) Elution rate(%)； (BB) Comparative embodiment 9； (CC) Comparative embodiment 10； (DD) Pletaal Tab.； (EE) Embodiment 7； (FF) Time(h)본 발명은 실로스타졸과 폴리메타크릴레이트 공중합체와의 고체분산체로서, 수-난용성 약물인 실로스타졸의 용해도를 현저하게 증가시킨 고체분산체； 및 이를 함유한 약학 조성물을 제공한다. 상기 약학 조성물은 생리학적 수성 매질 중에서 초기부터 신속하게 실로스타졸을 방출시킴으로써 높은 생체이용률을 달성할 수 있으며, 따라서 복용량을 감소시킬 수 있으므로 높은 안전성을 기대할 수 있다.
