SANCHES MARIO,SPRETER VON KREUDENSTEIN THOMAS,UROSEV DUNJA,TOM YEW Stacey A L,CORPER ADAM LOUIS,DANGELO Igor Edmondo Paolo,CHOU YANG CHIEH,DIXIT SURJIT BHIMARAO
申请号：
IN201647044175
公开号：
IN201647044175A
申请日:
2016.12.23
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
The present invention provides heterodimer pairs that can comprise a first heterodimer and a second heterodimer wherein each heterodimer comprises an immunoglobulin heavy chain or fragment thereof and an immunoglobulin light chain or fragment thereof. At least one of the heterodimers can comprise one or more amino acid modifications in the CH1 and/or CL domains one or more amino acid modifications in the VH and/or VL domains or a combination thereof. The modified amino acid(s) can be part of the interface between the light chain and heavy chain and are typically modified to create preferential pairing between each heavy chain and a desired light chain such that when the two heavy chains and two light chains of the heterodimer pair are co expressed in a cell the heavy chain of the first heterodimer preferentially pairs with one of the light chains rather than the other. Likewise the heavy chain of the second heterodimer typically preferentially pairs with the second light chain rather than first.
